What Are the Challenges Faced by Structural Biology in Cancer Research?
Despite its potential, structural biology in cancer research faces several challenges. One major challenge is the inherent complexity and heterogeneity of cancer, which makes it difficult to obtain high-quality crystals of certain proteins. Furthermore, many cancer-associated proteins are part of large complexes or exist in multiple conformational states, complicating their structural determination. Additionally, translating structural findings into effective therapies requires a multidisciplinary approach involving bioinformatics, genomics, and clinical trials.
