What are the Challenges in Anti-Angiogenic Therapy?
While anti-angiogenic therapies have shown promise, they are not without challenges. Tumors can develop resistance to these therapies by upregulating other pro-angiogenic factors or by activating alternative pathways. Additionally, inhibiting angiogenesis can sometimes lead to hypoxia (a lack of oxygen) within the tumor, which can make the cancer cells more aggressive and invasive.