Cancer cells can produce and release various pro-angiogenic factors to stimulate the formation of new blood vessels. One of the most well-studied factors is Vascular Endothelial Growth Factor (VEGF). When released, VEGF binds to receptors on the surface of endothelial cells, which line the interior surface of blood vessels. This binding triggers a series of signaling pathways that result in the proliferation and migration of endothelial cells, leading to the formation of new blood vessels.
