What are the Challenges in Establishing Dose-Response Relationships?
One of the key challenges is the variability in human population. Differences in age, sex, genetic predisposition, and lifestyle can all affect the dose-response relationship. Another challenge is the long latency period of many cancers, which makes it difficult to establish a direct cause-and-effect relationship. Additionally, the presence of multiple carcinogens and their potential interactions can complicate the analysis.