What Are the Challenges in Genomic and Transcriptomic Analysis?
Despite significant advancements, there are several challenges in genomic and transcriptomic analysis in cancer. One major challenge is the heterogeneity of cancer, where different cells within the same tumor can have distinct genetic and transcriptional profiles. This requires deep sequencing and single-cell analysis to capture the full complexity. Additionally, the large volume of data generated necessitates robust computational infrastructure and sophisticated analytical tools. Another challenge is the interpretation of variants of unknown significance (VUS), which requires functional studies to determine their role in cancer.
