What are the Challenges in Identifying Novel Fusion Genes?
Identifying novel fusion genes presents several challenges. Firstly, the sheer complexity and heterogeneity of cancer genomes require high-throughput and accurate techniques. Secondly, distinguishing driver fusion genes from passenger mutations is critical but challenging. Additionally, some fusion genes may be present at low frequencies, making them difficult to detect. Bioinformatics tools and algorithms play a crucial role in overcoming these challenges by analyzing large datasets to identify potential fusion events.
