What are the Challenges in Targeting Altered Target Sites?
While targeting altered sites offers a promising therapeutic approach, several challenges remain:
- Drug resistance: Tumors can develop resistance to targeted therapies through secondary mutations or activation of alternative pathways. - Heterogeneity: Cancer is a highly heterogeneous disease, and not all cells within a tumor may harbor the same genetic alterations. This makes treatment more complex. - Toxicity: Some targeted therapies can have off-target effects, causing toxicity and adverse reactions in patients.
