What are the Challenges in Targeting Alternative Splicing?
Despite the potential of targeting alternative splicing, several challenges remain. One major challenge is the complexity and redundancy of the splicing machinery, which can make it difficult to achieve specific and effective modulation of splicing events. Additionally, off-target effects and toxicity are concerns that need to be carefully addressed in the development of splicing-targeted therapies. Continuous research and advancements in high-throughput sequencing and bioinformatics are critical for overcoming these challenges and improving the efficacy of these therapeutic strategies.
