What Are the Challenges in Targeting Angiogenesis?
Despite the potential benefits, targeting angiogenesis in cancer therapy presents several challenges. Tumors can develop resistance to anti-angiogenic agents by activating alternative angiogenic pathways or increasing the expression of other pro-angiogenic factors. Additionally, the inhibition of angiogenesis can lead to hypoxia within the tumor, which may promote a more aggressive phenotype and enhance metastasis.
