What are the Challenges in Targeting BLM Helicase for Cancer Therapy?
One major challenge is the potential for off-target effects. BLM helicase is essential for normal cell function, and its inhibition could cause toxicity in healthy tissues. Additionally, cancer cells might develop resistance mechanisms to therapies targeting BLM helicase. Therefore, a precise understanding of BLM helicase function and regulation is crucial for developing effective and safe therapeutic strategies.
