What are the Challenges in Targeting DNA Repair Pathways for Cancer Therapy?
While targeting DNA repair pathways holds promise, there are several challenges. One major challenge is the development of resistance to therapies such as PARP inhibitors. Cancer cells can acquire secondary mutations that restore the function of the defective repair pathway or activate alternative repair mechanisms. Another challenge is the potential toxicity to normal cells, necessitating the development of strategies to specifically target cancer cells.
