Which Chromatin Modifying Complexes are Most Commonly Implicated in Cancer?
Several chromatin modifying complexes have been implicated in cancer, including:
SWI/SNF Complex: This ATP-dependent complex is involved in chromatin remodeling. Mutations in its subunits, such as SMARCA4 and ARID1A, are frequently found in cancers like ovarian and lung cancer. Polycomb Repressive Complexes (PRC1 and PRC2): These complexes are involved in maintaining gene silencing through histone modifications. Overexpression of PRC2 components like EZH2 is linked to aggressive prostate and breast cancers. Histone Deacetylases (HDACs): These enzymes remove acetyl groups from histones, leading to chromatin condensation and gene repression. HDAC inhibitors are being explored as therapeutic agents in various cancers.
