What Challenges Exist in Targeting Chromatin Modifying Complexes?
While targeting chromatin modifying complexes is promising, there are several challenges:
Specificity: Many chromatin modifiers have roles in normal cells, so achieving cancer-specific targeting without affecting normal tissue is challenging. Resistance: Cancer cells can develop resistance to chromatin-targeting drugs, necessitating combination therapies and novel agents. Toxicity: Given the essential roles of chromatin modifiers, their inhibition can lead to significant side effects, limiting the therapeutic window.
