How do Chromatin Modifying Complexes Influence Cancer?
The dysregulation of chromatin modifying complexes is a hallmark of many cancers. These complexes can influence cancer initiation, progression, and resistance to treatment. Aberrant modifications can lead to the activation of oncogenes or the silencing of tumor suppressor genes, thereby driving tumorigenesis. For instance, alterations in complexes like SWI/SNF and Polycomb Repressive Complexes (PRCs) are frequently observed in various cancers.
