What are the Challenges in Targeting ECM Modulators?
Targeting ECM modulators poses several challenges:
1. Complexity and Redundancy: The ECM is highly complex, and multiple modulators can compensate for each other, making it difficult to target a single molecule effectively. 2. Side Effects: Inhibiting ECM modulators can affect normal tissue homeostasis and lead to adverse effects. 3. Tumor Heterogeneity: Different tumors and even different regions within the same tumor can have varying ECM compositions, complicating the development of universal therapies.
