What are the Challenges in Targeting Enzymes for Cancer Therapy?
While targeting enzymes offers promising therapeutic avenues, several challenges exist:
- Specificity: Many enzymes are involved in normal cellular functions, so inhibitors must be highly specific to avoid off-target effects. - Resistance: Cancer cells can develop resistance to enzyme inhibitors through various mechanisms, such as mutations in the target enzyme or activation of compensatory pathways. - Delivery: Effective delivery of enzyme inhibitors to the tumor site while minimizing systemic toxicity remains a significant challenge.
