What are the Challenges in Targeting ER Stress in Cancer Therapy?
While targeting ER stress presents a novel approach to cancer treatment, there are several challenges:
Specificity: ER stress responses are also vital for the normal function of healthy cells, making it crucial to develop targeted therapies that minimize off-target effects. Resistance: Cancer cells may develop resistance to ER stress-targeting therapies through mutations or alternative survival pathways. Complexity: The UPR is a complex and highly regulated process, requiring a detailed understanding of its mechanisms in different cancer types to develop effective treatments.
