What are the Challenges in Targeting Nucleic Acids for Cancer Therapy?
While targeting nucleic acids offers great promise, several challenges remain:
- Delivery: Efficiently delivering nucleic acid-based therapies to tumor cells while avoiding healthy tissue is a significant hurdle. - Off-Target Effects: Ensuring specificity to avoid unintended genetic changes is crucial. - Resistance: Cancer cells can develop resistance to nucleic acid-based therapies, necessitating combination approaches and ongoing research.
