What are the Challenges in Targeting Salvage Pathways?
While targeting salvage pathways holds promise, several challenges exist. Cancer cells are highly adaptable and may develop compensatory mechanisms to bypass the blockade of salvage pathways. Additionally, these pathways are also crucial for the survival of normal cells, particularly in tissues with high turnover rates like the bone marrow and gastrointestinal tract. Therefore, inhibitors must be designed to selectively target cancer cells while sparing normal cells to minimize side effects.
