Are There Any Existing Drugs Targeting Salvage Pathways?
Some existing drugs do target enzymes within salvage pathways, albeit indirectly. For example, 5-fluorouracil (5-FU) is converted into active metabolites that inhibit thymidylate synthase and incorporate into RNA and DNA, disrupting their function. While not direct inhibitors of salvage pathways, these drugs highlight the potential of targeting nucleotide metabolism in cancer therapy.
