One of the main challenges in targeting TAMs is their plasticity. TAMs can quickly adapt to changes in the tumor microenvironment, making it difficult to sustain a therapeutic effect. Another challenge is the potential side effects of therapies that target TAMs, as these cells are also involved in normal immune responses and tissue homeostasis. Additionally, the heterogeneity of TAM populations within different tumors and even within different regions of the same tumor adds another layer of complexity to developing effective therapies.
