What are the Challenges in Targeting the MAPK Pathway?
Despite its potential, several challenges exist in targeting the MAPK pathway: 1. Drug resistance - Tumors often develop resistance through secondary mutations or activation of compensatory pathways. 2. Toxicity - Inhibiting components of the MAPK pathway can affect normal cells, leading to adverse effects. 3. Complexity - The pathway's intricate network and cross-talk with other signaling pathways complicate therapeutic targeting.
