What are the Challenges in Targeting the RB Pathway?
While targeting the RB pathway holds promise, several challenges exist: - Specificity: Ensuring that therapies specifically target cancer cells without affecting normal cells is crucial. - Resistance: Cancer cells may develop resistance to RB pathway-targeted therapies through compensatory mechanisms. - Complexity: The RB pathway interacts with numerous other signaling pathways, making it difficult to predict the outcomes of targeted interventions.
