Given its central role in cell cycle control, the RB pathway is an attractive target for cancer therapy. Strategies include: - CDK Inhibitors: Drugs that inhibit CDKs can prevent the phosphorylation of pRB, thereby reactivating its tumor suppressor functions. - Gene Therapy: Approaches to restore functional RB1 in cancer cells are being explored. - Immune Modulation: Some therapies aim to boost the immune system's ability to recognize and eliminate cancer cells with RB pathway defects.
