What are the Challenges in Targeting the TERT Promoter?
Despite its potential, targeting the TERT promoter and telomerase activity presents several challenges. One significant issue is the potential for off-target effects, as telomerase is also essential for the maintenance of stem cells and tissue regeneration. Additionally, cancer cells may develop resistance mechanisms to telomerase inhibition. Therefore, a comprehensive understanding of the molecular context and combination with other therapeutic approaches is necessary to enhance treatment efficacy.
