Can TERT Promoter Mutations be Targeted for Therapy?
Given its critical role in cancer cell survival, the TERT promoter is an attractive target for therapeutic intervention. Several strategies are being explored to target TERT and telomerase activity, including small molecule inhibitors, immunotherapy, and gene editing techniques like CRISPR/Cas9. Inhibiting telomerase activity in cancer cells can induce telomere shortening, leading to cell death and reduced tumor growth.
