What Are the Challenges in Using Gene Ontology for Cancer Research?
While Gene Ontology offers valuable insights, there are challenges:
- Incomplete or inaccurate annotations: Not all genes have comprehensive or correct GO terms assigned. - Complexity of cancer biology: Cancer involves numerous interacting pathways, making it difficult to attribute changes to specific GO terms. - Dynamic nature of gene functions: Gene functions can vary depending on the cellular context and environmental factors, complicating the application of static GO terms.
