What are the challenges of immunotherapy in cancer treatment?
Despite the promising potential of immunotherapies, there are several challenges associated with their use:
_Immune-related adverse events (irAEs)_: These can occur when the immune system attacks normal tissues, leading to inflammation and damage in organs such as the skin, liver, and lungs. _Heterogeneity of tumors_: Tumors can be highly heterogeneous, meaning that different cells within the same tumor may express different antigens, making it difficult for immunotherapies to target all cancer cells effectively. _Resistance_: Cancer cells can develop resistance to immunotherapies through mechanisms such as antigen loss or upregulation of alternative immune checkpoint pathways.
