dna damaging agents

What are the Challenges of Using DNA Damaging Agents?

Despite their effectiveness, the use of DNA damaging agents comes with significant challenges. One major issue is the lack of selectivity, which can lead to damage in healthy cells and subsequent side effects. Resistance is another major hurdle; cancer cells can develop or possess mechanisms to repair DNA damage or evade the effects of these agents. This resistance can limit the efficacy of treatment and lead to recurrence. Moreover, the accumulation of DNA damage in normal cells over time can increase the risk of secondary cancers.

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