The clinical features of MEN2 can vary depending on the subtype and the specific endocrine glands involved. Some common symptoms and signs include:
Medullary Thyroid Carcinoma (MTC): Early symptoms may include a thyroid nodule, neck pain, or swelling. If left untreated, it can spread to other parts of the body.
Pheochromocytoma: These tumors of the adrenal glands can cause high blood pressure, palpitations, sweating, and headaches.
Hyperparathyroidism: This condition leads to elevated calcium levels in the blood, resulting in kidney stones, bone pain, and abdominal pain.
Mucosal Neuromas: These benign growths can occur on the lips, tongue, and lining of the mouth, particularly in MEN2B.
Marfanoid Habitus: Individuals with MEN2B may exhibit physical characteristics similar to those seen in Marfan syndrome, such as long limbs and a tall, slender build.
