What are the Clinical Implications of Targeting APBs?
Targeting APBs or their associated proteins could offer a novel avenue for cancer therapy, particularly for ALT-positive cancers that do not respond well to telomerase inhibitors. By disrupting the formation or function of APBs, researchers hope to impair the telomere maintenance in these cancer cells, leading to cellular senescence or apoptosis. Some experimental approaches include the use of small molecules or peptides that specifically disrupt protein-protein interactions within APBs.
