What are the Components of the 3D Tumor Microenvironment?
The 3D TME consists of various components that interact with each other to influence tumor growth and progression. These include:
Cancer-associated fibroblasts (CAFs): They secrete growth factors, cytokines, and extracellular matrix proteins that promote tumor growth and metastasis. Immune cells: Such as T-cells, macrophages, and natural killer cells, which can either suppress or promote cancer depending on their phenotype and the signals they receive. Endothelial cells: These form the blood vessels that supply nutrients and oxygen to the tumor, facilitating its growth and the potential for metastasis. Extracellular matrix (ECM): A network of proteins and polysaccharides that provide structural support and influence cell behavior through biochemical and mechanical signals.
