What are the Different Types of DNA Sequencing Technologies?
Several DNA sequencing technologies are used in cancer research:
Sanger Sequencing: The first widely used method, now primarily used for smaller-scale projects and validation of NGS results. Next-Generation Sequencing (NGS): Allows high-throughput sequencing, providing a more comprehensive view of the cancer genome. Whole Genome Sequencing (WGS): Sequences the entire genome, offering insights into both coding and non-coding regions of DNA. Whole Exome Sequencing (WES): Focuses on sequencing the exome, the protein-coding regions of the genome, which are most likely to contain disease-related mutations. RNA Sequencing (RNA-Seq): Analyzes the transcriptome, providing information on gene expression and uncovering potential regulatory mechanisms in cancer.
