Future research is focused on better understanding the mechanisms underlying antigen loss and developing innovative strategies to counteract this phenomenon. Scientists are exploring the use of next-generation sequencing and other advanced technologies to identify new tumor antigens and understand the genetic and epigenetic changes driving antigen loss. Additionally, there is a growing interest in designing combination therapies that can prevent or overcome antigen loss, as well as in developing personalized immunotherapies tailored to the unique antigenic landscape of each patient's tumor.
