Preventing or reversing antigen loss is an area of active research. Strategies being explored include combination therapies that target multiple antigens simultaneously, thereby reducing the likelihood of antigen-negative escape variants. Additionally, researchers are investigating ways to modulate gene expression to restore the presentation of lost antigens, such as using epigenetic drugs to reverse DNA methylation. Furthermore, novel approaches like neoantigen vaccines aim to generate a robust immune response against a broader range of tumor-specific antigens, potentially overcoming the challenge of antigen loss.
