What Are the Implications of NHEJ Deficiency in Cancer?
Deficiencies in NHEJ components can lead to increased sensitivity to DNA-damaging agents, such as ionizing radiation and certain chemotherapies. For example, defects in DNA-PKcs or Ligase IV can impair DSB repair, making cancer cells more vulnerable to treatment. Conversely, upregulation of NHEJ components may contribute to treatment resistance, posing a challenge for effective cancer therapy.
