What Are the Implications of CYP450 Polymorphisms?
Genetic variations in CYP450 enzymes, known as polymorphisms, can lead to significant interindividual differences in drug metabolism. Polymorphisms can result in enzymes with reduced, absent, or enhanced activity. For example, variations in CYP2D6 can affect the metabolism of tamoxifen, a drug commonly used in the treatment of breast cancer. Patients with certain polymorphisms may require dose adjustments to achieve optimal therapeutic outcomes.
