There is evidence to suggest that altered CYP450 activity might be associated with an increased risk of certain cancers. For example, CYP1A1 is involved in the activation of procarcinogens found in tobacco smoke. Higher activity of this enzyme may increase the risk of lung cancer among smokers. Additionally, CYP2E1 metabolizes ethanol to acetaldehyde, a known carcinogen, suggesting a potential link to alcohol-related cancers.
