What are the Implications of NHEJ in Cancer Therapy?
The role of NHEJ in cancer therapy is multifaceted:
Therapeutic resistance: Enhanced NHEJ activity can make cancer cells resistant to treatments that induce DNA breaks, such as radiotherapy. Targeted therapy: Inhibitors of NHEJ components, like DNA-PKcs and Ligase IV, are being developed to increase the efficacy of DNA-damaging agents. Biomarker potential: Levels of NHEJ activity could serve as biomarkers to predict treatment response and tailor personalized therapies.
