What are the Key Changes in the Transcriptome in Cancer?
Several key changes in the transcriptome are often observed in cancer: 1. Overexpression or Underexpression of Genes: Certain oncogenes may be overexpressed, while tumor suppressor genes may be underexpressed. 2. Alternative Splicing: Cancer cells often exhibit abnormal splicing patterns, leading to the production of protein variants that can promote cancer. 3. Non-coding RNAs: Changes in the expression of non-coding RNAs, such as microRNAs and long non-coding RNAs, can contribute to cancer by regulating gene expression at the post-transcriptional level.
