What Are the Key Factors Influencing the EPR Effect?
Several factors can influence the efficiency of the EPR effect:
Tumor Type: Different tumors have varying vascular structures, which can affect the degree of EPR. Molecular Size and Shape: The size and shape of the drug or nanoparticle can impact its ability to penetrate and accumulate in tumor tissues. Blood Flow: Adequate blood flow is necessary to transport the therapeutic agents to the tumor site. Extracellular Matrix: The density and composition of the extracellular matrix can either facilitate or hinder the penetration of nanoparticles. Tumor Microenvironment: Factors like hypoxia and interstitial fluid pressure can also play a significant role.
