What is Enhanced Permeability and Retention (EPR) Effect?
The Enhanced Permeability and Retention (EPR) effect is a phenomenon observed in the field of oncology, particularly in the delivery of cancer therapeutics. This effect refers to the tendency of nanoparticles and macromolecules to accumulate in tumor tissues more than in normal tissues. The EPR effect is primarily due to the unique characteristics of tumor vasculature, which includes leaky blood vessels and poor lymphatic drainage.
