Multi-source Integration: Funcotator integrates data from multiple sources to provide a comprehensive annotation of each variant. Customizable Annotations: Users can specify which data sources to use and customize the annotation process to fit their specific needs. High-throughput Capability: Funcotator is designed to handle large datasets, making it suitable for high-throughput sequencing projects. Detailed Output: The tool provides detailed information about each variant, including gene name, variant type, predicted protein impact, and clinical significance.