What Are the Key Mechanisms of Dysregulated Replication?
Several mechanisms contribute to dysregulated replication in cancer:
Oncogenes: Genes that promote cell growth and division. When mutated, they can become hyperactive. Tumor Suppressors: Genes that inhibit cell division. Mutations can inactivate these genes, removing the brakes on cell proliferation. Telomere Shortening: Normally, telomeres shorten with each cell division, limiting the number of times a cell can divide. In cancer, the enzyme telomerase is often activated, maintaining telomere length and allowing endless division.
