Despite its benefits, Lung-RADS has some limitations. One significant issue is its sensitivity and specificity. While Lung-RADS aims to balance false positives and negatives, it is not foolproof. There is still a risk of missing early-stage cancers or over-diagnosing benign nodules. Additionally, Lung-RADS may not be as effective for high-risk populations or those with a history of previous cancers.