What are the mechanisms of immune evasion by cancer cells?
Cancer cells employ several strategies to evade the immune system. They can downregulate the expression of TAAs, produce immunosuppressive molecules like TGF-beta, and create an immunosuppressive microenvironment. Additionally, they can express immune checkpoint proteins such as PD-L1, which interact with PD-1 receptors on T-cells to inhibit their activity.
