What Are the Mechanisms of Resistance to Cancer Therapy?
Cancer cells can develop resistance to therapies through various mechanisms, including genetic mutations, alterations in drug targets, activation of alternative signaling pathways, and enhanced drug efflux. For example, mutations in the epidermal growth factor receptor (EGFR) can render targeted therapies ineffective. Additionally, cancer stem cells are believed to contribute to therapy resistance and tumor recurrence due to their ability to self-renew and differentiate.
