What Are the Mechanisms Through Which Vinyl Chloride Causes Cancer?
Vinyl chloride is metabolized in the liver to reactive intermediates, such as chloroethylene oxide and chloroacetaldehyde, which can bind to DNA and proteins. This binding causes genetic mutations and other cellular damage, leading to uncontrolled cell growth and cancer. Additionally, these intermediates can generate reactive oxygen species (ROS), which can further damage cellular components and contribute to carcinogenesis.
