While epothilones are generally well-tolerated, they do have side effects. Common adverse effects include: 1. Neuropathy: Although less severe than with taxanes, neuropathy can still be a significant side effect. 2. Myelosuppression: This includes anemia, neutropenia, and thrombocytopenia, which can increase the risk of infections and bleeding. 3. Gastrointestinal Distress: Nausea, vomiting, and diarrhea are also reported.