What Are the Clinical Applications of Epothilones?
Epothilones are primarily used in the treatment of cancers that are resistant to other forms of chemotherapy. Specific clinical applications include: 1. Breast Cancer: Ixabepilone, in combination with capecitabine, is approved for patients with metastatic breast cancer who have previously been treated with an anthracycline and a taxane. 2. Prostate Cancer: Studies have shown potential benefits of epothilones in castration-resistant prostate cancer. 3. Ovarian Cancer: Clinical trials are exploring the use of epothilones in overcoming platinum-based chemotherapy resistance in ovarian cancer.
